Whom portrays Mrs. Wheeler Wheeler? What actor embodies the role of Karen Wheeler in the show? Whom is the performer behind Karen Wheeler? Mrs. Wheeler is depicted by whom? What actress plays the character of Karen Wheeler on the series? Who is the talent showcasing Karen the mother's character to life? What performer takes on the role of Karen Mrs. Wheeler in the television show? Who takes on the part of Karen Mrs. Wheeler? Whom is the talented individual embodying Karen Wheeler on the series? Which actor embodies the character of Karen Mrs. Wheeler to the screen?